Know your Glycolytic enzymes

We all know that in glycolysis there are 10 reactions controlled by 10 enzymes. These are:

Phase 1                                                                          

  • Hexokinase: It catalyses alpha D-Glucose and ATP to Glucose-6-Phosphate (G6P) and ADP by phosphorylation.
  • Phosphoglucose isomerase: This catalyses G6P to its isomer Fructose-6-phosphate (F6P). This occurs by changing the carbonyl oxygen from the C1 position on the G6P to the C2 position on F6P
  •  Phosphofructokinase: Catalyses F6P and ATP to Fructose-1, 6-Bisphosphate (F1, 6PP) and ADP.
  • Fructose-Bisphosphate aldolase: Catalyses F1,6PP to split into  Dihydroxyacetone Phosphate (DHAP) and Glyceraldehyde-3-Phosphate (G3P)
  • Triosephosphate isomerase: This catalyses DHAP to turn into G3P because only G3P can be used in the reaction.

Phase 2

  • Glyceraldehyde-3-phosphate dehydrogenase:  Catalyses G3P, NAD and Pi to 1,3 Bisphosphoglycerate (1,3 BPG), NADH and H+
  • Phosphoglycerate kinase: Catalyses 1,3 BPG and ADP to 3-Phosphoglycerate and ATP
  • Phosphoglycerate mutase: Catalyses 3PG to 2-Phosphoglycerate (2PG)
  • Enolase: Catalyses 2PG to Phosphoenolpyruvate (PEP) and H2O.
  • Pyruvate kinase: It catalyses PEP and ADP to Pyruvate and ATP.

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Posted on March 17, 2014, in Uncategorized and tagged , . Bookmark the permalink. Leave a comment.

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