10 Glycolysis Facts
1. Glycolysis aka the Embden-Meyerhof-Parnas pathway (EMP pathway) was discovered by Gustav Embden, Otto Meyerhof and Jakub Karol Parnas.
2. The Glycolysis process is so old that it has probably been around before oxygen made its debut in the atmosphere.
3. Glyco –glucose Lysis- splits. It basically is the conversion of one 6-carbon glucose molecule into two 3-carbon sugars called pyruvate through a series of enzymatic reactions.
4. It involves two phases, the Preparatory phase or the energy investment phase and the energy generation phase or the payoff phase.
5. In the investment phase, initially 2 ATP molecules are invested in glycolysis. The payoff is the generation of 4 ATP molecules so a profit or net gain of 2 ATP molecules is made.
6. Glycolysis involves 10 reactions each being catalyzed by one of ten enzymes, in the following order Hexokinase, Phosphohexose Isomerase, Phospho- fructokinase -1, Aldose, Triose phosphate isomerase, Glyceraldehyde 3- phosphate, Phosphoglycerate kinase, Phosphoglycerate mutase, Enolase and finally Pyruvate kinase.
7. It occurs in plant and animal cells and the cells of microbes.
8. It occurs in the cytoplasm of prokaryotes and the cytosol of eukaryotes.
9. Under anaerobic conditions, glycolysis causes cells to produce ATP. This process is called fermentation.
10. Under aerobic conditions, glycolysis is the first phase of cellular respiration.